Police are advising motorists to avoid Boroughbridge Road in Knaresborough following a collision involving a car and two pedestrians.
Boroughbridge Road is currently closed near the garage, at the junction of Tentergate Lane.
It is expected to stay closed for around an hour while police and ambulance crews deal with the incident.
Local diversions are in place, but drivers are advised to use alternative routes during rush hour and avoid the area entirely if possible.
The two pedestrians involved have been taken to Harrogate Hospital.